Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Base Information

Chemical Name:Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
CAS No.:794491-71-7
Molecular Formula:C₂₄H₃₂N₅O₁₄P
Molecular Weight:645.517
Hs Code.:

Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Synonyms:Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

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Chemical Property of Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

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Technology Process of Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

There total 9 articles about Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362-43-6
2',3'-O-isopropylideneuridine

: 794491-71-7
Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / Pd(OAc)2 / acetonitrile

2: H₂ / Pd(OH)2

3: aq. KOH

4: 78 percent / TBTU; DIEA / dimethylformamide

5: POCl₃; PO(OEt)3

6: aq. HCl

With hydrogenchloride; potassium hydroxide; triethyl phosphate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium diacetate; palladium dihydroxide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2004-829563

Reference yield:

: 5-(2-propenoic acid)-2',3'-O-isopropylidene uridine ethyl ester

: 794491-71-7
Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd(OH)2

2: aq. KOH

3: 78 percent / TBTU; DIEA / dimethylformamide

4: POCl₃; PO(OEt)3

5: aq. HCl

With hydrogenchloride; potassium hydroxide; triethyl phosphate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium dihydroxide; In N,N-dimethyl-formamide;
DOI:10.1055/s-2004-829563

Reference yield:

: 773150-16-6
2-amino-3-(4-hydroxy-3-nitro-phenyl)-N-propyl-propionamide

: 794491-71-7
Phosphoric acid mono-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-{2-[(R)-2-(4-hydroxy-3-nitro-phenyl)-1-propylcarbamoyl-ethylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / TBTU; DIEA / dimethylformamide

2: POCl₃; PO(OEt)3

3: aq. HCl

With hydrogenchloride; triethyl phosphate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1055/s-2004-829563