1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

Base Information

Chemical Name:1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine
CAS No.:154535-25-8
Molecular Formula:C₂₀H₂₂N₆O₂
Molecular Weight:378.434
Hs Code.:

Synonyms:1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

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Chemical Property of 1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

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Technology Process of 1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

There total 1 articles about 1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 311-77-3,1186-46-5
1,1-dimethylguanidine dihydrogensulfate

: 154535-18-9
6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

: 4-(1,3-Diamino-pyrrolo[3',4':4,5]pyrido[2,3-d]pyrimidin-8-yl)-benzoic acid tert-butyl ester

: 154535-25-8
1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) DMF, RT, 1 h, 2.) DMF, 18 h;
DOI:10.1002/jhet.5570300542

Reference yield: 98.0%

: 154535-25-8
1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

: 154535-22-5
1,3-diamino-8-(hydroxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at -10 ℃; for 1.5h;
DOI:10.1002/jhet.5570300542

Reference yield:

: 154535-25-8
1,3-diamino-8-(t-butoxycarbonylphenyl)-7,8-dihydro-9H-pyrrolo<3',4':4,5>pyrido<2,3-d>pyrimidine

: N-<4-(1,3-diamino-pyrrolo<3'.4':4,5>pyrido<2,3-d>pyrimidin-8-yl)benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / trifluoroacetic acid / CH₂Cl₂ / 1.5 h / -10 °C

2: 1.) methylenemorpholine, 2.) isobutyl chloroformate, 3.) 4-methylmorpholine

3: 56 percent / HCl / nitromethane / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; methylenemorpholine; trifluoroacetic acid; isobutyl chloroformate; In nitromethane; dichloromethane;
DOI:10.1002/jhet.5570300542