(Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one

Base Information

• Chemical Name: (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one
• CAS No.: 865082-12-8
• Molecular Formula: C₂₉H₂₀F₃NO
• Molecular Weight: 455.479
• Mol file: 865082-12-8.mol

Synonyms:(Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one

Chemical Property of (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one

There total 2 articles about (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenylboronic acid (98-80-6) + N-benzyl-3-(4-(trifluoromethyl)phenyl)-N-(2-iodophenyl)propiolamide → (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one (865082-12-8)

Guidance literature:

With palladium diacetate; triphenylphosphine; cesium fluoride; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1021/jo0508604

Reference yield: 78.0%

4-Iodobenzotrifluoride (455-13-0) + 3-phenyl-propynoic acid benzyl-(2-iodophenyl)amide → (Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one (865082-12-8)

Guidance literature:

3-phenyl-propynoic acid benzyl-(2-iodophenyl)amide; With indium; bromine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

4-Iodobenzotrifluoride; With lithium bromide; palladium(II) acetylacetonate; at 100 ℃;

DOI:10.1021/ol048866n

Reference yield:

(Z)-1-benzyl-3-[(4-trifluoromethylphenyl)(phenyl)methylene]indolin-2-one (865082-12-8) → (E)-3-{[(4-trifluoromethyl)phenyl](phenyl)methylene}indolin-2-one + (Z)-3-{[(4-trifluoromethyl)phenyl](phenyl)methylene}indolin-2-one

Guidance literature:

With N-hydroxyphthalimide; oxygen; cobalt(II) acetate; manganese(II) acetate; In acetic acid; at 100 ℃; for 12h; under 760 Torr; Title compound not separated from byproducts;

DOI:10.1002/adsc.200505147

upstream raw materials:

4-Iodobenzotrifluoride

phenylboronic acid