2-Fluoro-2-phenyl-2-phenylthioacetonitrile

Base Information

• Chemical Name: 2-Fluoro-2-phenyl-2-phenylthioacetonitrile
• CAS No.: 210217-98-4
• Molecular Formula: C₁₄H₁₀FNS
• Molecular Weight: 243.305
• Mol file: 210217-98-4.mol

Synonyms:2-Fluoro-2-phenyl-2-phenylthioacetonitrile

Chemical Property of 2-Fluoro-2-phenyl-2-phenylthioacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-Fluoro-2-phenyl-2-phenylthioacetonitrile

There total 1 articles about 2-Fluoro-2-phenyl-2-phenylthioacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

α-(phenylthio)-benzyl cyanide (32121-59-8) → 2-Fluoro-2-phenyl-2-phenylthioacetonitrile (210217-98-4)

Guidance literature:

With N-fluoropyridinium triflate; In 1,2-dichloro-ethane; for 3.5h; Heating;

DOI:10.1055/s-1999-3438

Reference yield: 95.0%

1-chloro-3,7-dimethylocta-2,6-diene (5389-87-7) + 2-Fluoro-2-phenyl-2-phenylthioacetonitrile (210217-98-4) → (E)-2-Fluoro-5,9-dimethyl-2-phenyl-deca-4,8-dienenitrile

Guidance literature:

With Triethylgermyl-natrium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1.) -60 deg C, 0.25 h, 2.) -80 deg C, 0.5 h;

DOI:10.1039/a802005a

Reference yield: 94.0%

diphenylcarbamic chloride (83-01-2) + 2-Fluoro-2-phenyl-2-phenylthioacetonitrile (210217-98-4) → N,N-Diphenyl-2-cyano-2-fluoro-2-phenylacetoamide

Guidance literature:

2-Fluoro-2-phenyl-2-phenylthioacetonitrile; With Triethylgermyl-natrium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -60 ℃; for 0.25h;

diphenylcarbamic chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -80 ℃; for 0.5h;

DOI:10.1055/s-1999-3543

upstream raw materials:

α-(phenylthio)-benzyl cyanide