Benzeneacetic acid, 5-bromo-2-nitro-, methyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 5-bromo-2-nitro-, methyl ester
• CAS No.: 189748-25-2
• Molecular Formula: C₉H₈BrNO₄
• Molecular Weight: 274.071
• Hs Code.: 2916399090
• Mol file: 189748-25-2.mol

Synonyms:2-(5-bromo-2-nitrophenyl)acetic acid methyl ester;methyl 2-(5-bromanyl-2-nitro-phenyl)ethanoate;

Chemical Property of Benzeneacetic acid, 5-bromo-2-nitro-, methyl ester

Chemical Property:

• PSA: 72.12000
• LogP: 2.59600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(5-bromo-2-nitrophenyl)acetate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 5-bromo-2-nitro-, methyl ester

There total 2 articles about Benzeneacetic acid, 5-bromo-2-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

dimethyl 2-(5-bromo-2-nitrophenyl)malonate (1417407-96-5) → methyl 2-(5-bromo-2-nitrophenyl)acetate (189748-25-2)

Guidance literature:

With water; In dimethyl sulfoxide; Reflux; Inert atmosphere;

DOI:10.1021/ja3113565

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → methyl 2-(5-bromo-2-nitrophenyl)acetate (189748-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

2: water / dimethyl sulfoxide / Reflux; Inert atmosphere

With water; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ja3113565

Reference yield: 57.0%

aniline (62-53-3) + methyl 2-(5-bromo-2-nitrophenyl)acetate (189748-25-2) → methyl 2-(2-nitro-5-(phenylamino)phenyl)acetate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; Inert atmosphere;

upstream raw materials:

dimethyl 2-(5-bromo-2-nitrophenyl)malonate

4-bromo-2-fluoronitrobenzene

Refernces