4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

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Chemical Name:4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide
CAS No.:1429660-08-1
Molecular Formula:C₂₄H₂₀ClF₆N₃O₄
Molecular Weight:563.884
Hs Code.:

Synonyms:4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

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Chemical Property of 4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

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Technology Process of 4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

There total 4 articles about 4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309959-46-3
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

: (4R)-4-amino-2-ethyl-isoxazolidin-3-one trifluoroacetate

: 1429660-09-2
C₂₄H₂₀ClF₆N₃O₄

: 1429660-08-1
4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

Guidance literature:: 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 18.5h;

(4R)-4-amino-2-ethyl-isoxazolidin-3-one trifluoroacetate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 928783-56-6
1-chloro-3-(trifluoromethyl)-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1429660-09-2
C₂₄H₂₀ClF₆N₃O₄

: 1429660-08-1
4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; triethylamine / toluene / 0.17 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18.5 h / 20 °C

3.2: 3 h / 20 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 1429660-28-5
tert-butyl 4-[(Z)-C-chloro-N-hydroxy-carbonimidoyl]-2-methyl-benzoate

: 1429660-09-2
C₂₄H₂₀ClF₆N₃O₄

: 1429660-08-1
4-[(5S)-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; triethylamine / toluene / 0.17 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18.5 h / 20 °C

3.2: 3 h / 20 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; toluene;