4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Base Information

Chemical Name:4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline
CAS No.:868662-44-6
Molecular Formula:C₁₉H₁₂Cl₂F₃N₃O
Molecular Weight:426.225
Hs Code.:

Synonyms:4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

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Chemical Property of 4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

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Technology Process of 4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

There total 4 articles about 4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (E)-4-(4-Chloro-phenyl)-1,1,1-trifluoro-4-methoxy-but-3-en-2-one

: 23834-14-2
7-chloro-4-hydrazinoquinoline

: 868662-44-6
4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: In methanol; at 64 ℃;
DOI:10.1002/jhet.5570420604

Reference yield:

: 72360-69-1
4-chlorophenyl methyl ketone dimethyl acetal

: 868662-44-6
4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CHCl₃ / 16 h / 0 - 45 °C

2: methanol / Heating

With pyridine; In methanol; chloroform;
DOI:10.1016/j.bmcl.2005.10.033

Reference yield:

: 99-91-2
para-chloroacetophenone

: 868662-44-6
4-[3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH / methanol / 24 h / 20 °C

2: pyridine / CHCl₃ / 16 h / 0 - 45 °C

3: methanol / Heating

With pyridine; toluene-4-sulfonic acid; In methanol; chloroform;
DOI:10.1016/j.bmcl.2005.10.033