[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

Base Information

Chemical Name:[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone
CAS No.:1241898-43-0
Molecular Formula:C₁₇H₂₂FNO
Molecular Weight:275.366
Hs Code.:

Synonyms:[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

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Chemical Property of [2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

Chemical Property:

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Technology Process of [2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

There total 3 articles about [2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-42-9
(2-bromo-5-fluorophenyl)(1-methylpiperidin-4-yl)methanone

: 4619-93-6
(cyclopropylmethyl)magnesium bromide

: 1241898-43-0
[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

Guidance literature:: (cyclopropylmethyl)magnesium bromide; With manganese chloride bis(lithium chloride); In tetrahydrofuran; at -78 - -46 ℃;

(2-bromo-5-fluorophenyl)(1-methylpiperidin-4-yl)methanone; In tetrahydrofuran; at -78 - -20 ℃;

Reference yield:

: 5570-77-4
4-chloro-1-methylpiperidine

: 1241898-43-0
[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 2 h / 20 °C / Reflux

2.1: oxalyl dichloride / 1,2-dichloro-ethane / 6 h / 20 - 70 °C

2.2: -78 - 20 °C

2.3: Cooling with ice

3.1: manganese chloride bis(lithium chloride) / tetrahydrofuran / -78 - -46 °C

3.2: 2 h / -78 - -20 °C

With oxalyl dichloride; manganese chloride bis(lithium chloride); magnesium; ethylene dibromide; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

: 63463-36-5
(1-methyl-4-piperidyl)magnesium chloride

: 1241898-43-0
[2-(cyclopropylmethyl)-5-fluorophenyl](1-methylpiperidin-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / 1,2-dichloro-ethane / 6 h / 20 - 70 °C

1.2: -78 - 20 °C

1.3: Cooling with ice

2.1: manganese chloride bis(lithium chloride) / tetrahydrofuran / -78 - -46 °C

2.2: 2 h / -78 - -20 °C

With oxalyl dichloride; manganese chloride bis(lithium chloride); In tetrahydrofuran; 1,2-dichloro-ethane;