3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan

Base Information

• Chemical Name: 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan
• CAS No.: 149838-26-6
• Molecular Formula: C₂₅H₃₈N₂O₆Si
• Molecular Weight: 490.672
• Mol file: 149838-26-6.mol

Synonyms:3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan

Chemical Property of 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan

There total 3 articles about 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tyrosamine (51-67-2) → 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan (149838-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / aq. NaOH / dioxane / 1.5 h / 0 - 20 °C

2: KOH, n-Bu₄NBr / tetrahydrofuran / 3 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/ja00068a022

Reference yield:

2-(trimethylsilyl)-ethoxycarbonyl chloride (20160-60-5) → 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan (149838-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / aq. NaOH / dioxane / 1.5 h / 0 - 20 °C

2: KOH, n-Bu₄NBr / tetrahydrofuran / 3 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/ja00068a022

Reference yield:

p-<β-(((trimethylsilylethoxy)carbonyl)amino)ethyl>phenol (149838-25-5) + Methanesulfonic acid 5-(tert-butoxycarbonylamino-methyl)-furan-3-ylmethyl ester → 3-phenoxymethyl>-5-(((tert-butyloxycarbonyl)amino)methyl)furan (149838-26-6)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/ja00068a022

upstream raw materials:

p-<β-(((trimethylsilylethoxy)carbonyl)amino)ethyl>phenol

tyrosamine

2-(trimethylsilyl)-ethoxycarbonyl chloride

Downstream raw materials:

3--5-(((tert-butoxycarbonyl)amino)methyl)furan

3-phenoxymethyl>-5-(((tert-butoxycarbonyl)amino)methyl)furan, tetra-tert-butyl ester

3-phenoxymethyl>-5-(((tert-butoxycarbonyl)amino)methyl)furan, tri-tert-butyl ester

3-phenoxymethyl>-5-(((tert-butoxycarbonyl)amino)methyl)furan, di-tert-butyl ester