5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

Base Information

Chemical Name:5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one
CAS No.:1610458-07-5
Molecular Formula:C₂₀H₁₆F₃N₅O₂
Molecular Weight:415.375
Hs Code.:

Synonyms:5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

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Chemical Property of 5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

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Technology Process of 5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

There total 14 articles about 5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610458-29-1
tert-butyl ((7R,8S)-3-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

: 1610458-07-5
5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 1384126-47-9
1,2,4-trifluoro-5-(3-methoxy-6-nitrocyclohex-3-enyl)benzene

: 1610458-07-5
5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-Bromosuccinimide; sodium acetate / water; tetrahydrofuran / 0.5 h / 0 °C

2.1: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

3.1: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

5.1: hydrogenchloride / water / 24 h / 100 °C / pH 12

6.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

7.1: hydrogenchloride / water / 100 °C

8.1: potassium carbonate / methanol / 20 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

9.2: 3 h / 0 - 20 °C

10.1: tetrahydrofuran / 20 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice

12.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384126-46-8
2-bromo-4-nitro-5-(2,4,5-trifluorophenyl)cyclohexanone

: 1610458-07-5
5-((7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-3-yl)-3-methyl-1,3,4-oxadiazol-2(3H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

2.1: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / water / 24 h / 100 °C / pH 12

5.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

6.1: hydrogenchloride / water / 100 °C

7.1: potassium carbonate / methanol / 20 °C

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

8.2: 3 h / 0 - 20 °C

9.1: tetrahydrofuran / 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice

11.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;