5-(Difluoromethoxy)pyridin-2-amine

Base Information

• Chemical Name: 5-(Difluoromethoxy)pyridin-2-amine
• CAS No.: 110861-14-8
• Molecular Formula: C₆H₆F₂N₂O
• Molecular Weight: 160.123
• Hs Code.: 2933399990
• European Community (EC) Number: 826-661-2
• DSSTox Substance ID: DTXSID60562755
• Nikkaji Number: J336.260D
• Wikidata: Q82447024
• Mol file: 110861-14-8.mol

Synonyms:5-(DIFLUOROMETHOXY)PYRIDIN-2-AMINE;110861-14-8;2-Pyridinamine, 5-(difluoromethoxy)-;5-difluoromethoxy-pyridin-2-ylamine;5-(difluoromethoxy)-2-pyridinamine;C6H6F2N2O;5-(difluoromethoxy)pyridine-2-amine;SCHEMBL1002255;DTXSID60562755;MFCD11977404;AKOS015909065;AT30073;SB30672;[5-(difluoro-methoxy)-pyridin-2-yl]-amine;CS-0132705;EN300-221383;A802258;Z1255492866

Chemical Property of 5-(Difluoromethoxy)pyridin-2-amine

Chemical Property:

• PSA: 48.87000
• LogP: 1.19530
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 160.04481914
• Heavy Atom Count: 11
• Complexity: 123

Purity/Quality:

97% ^*data from raw suppliers

5-(Difluoromethoxy)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1OC(F)F)N

Technology Process of 5-(Difluoromethoxy)pyridin-2-amine

There total 2 articles about 5-(Difluoromethoxy)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(5-Difluoromethoxy-pyridin-2-yl)-(4-nitro-phenyl)-diazene (110861-12-6) → 5-(difluoromethoxy)pyridine-2-amine (110861-14-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 25 - 28 ℃; for 8h; under 42753.4 Torr;

DOI:10.1055/s-1990-26980

Reference yield:

6-[2-(4-nitrophenyl)diazenyl]-3-pyridinol (35771-41-6) → 5-(difluoromethoxy)pyridine-2-amine (110861-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / K₂CO₃ / dimethylformamide / 6.5 h / 80 - 90 °C

2: 57 percent / H₂ / 10percent Pd/C / acetic acid / 8 h / 25 - 28 °C / 42753.4 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1055/s-1990-26980

upstream raw materials:

(5-Difluoromethoxy-pyridin-2-yl)-(4-nitro-phenyl)-diazene

6-[2-(4-nitrophenyl)diazenyl]-3-pyridinol

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