cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Base Information

Chemical Name:cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide
CAS No.:85234-85-1
Molecular Formula:C₂₃H₂₉N₃O₂
Molecular Weight:379.502
Hs Code.:

Synonyms:cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

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Chemical Property of cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

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Technology Process of cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

There total 2 articles about cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 122-78-1
phenylacetaldehyde

: 85221-47-2
(2S,4R)-4-(Phenyl-propionyl-amino)-piperidine-2-carboxylic acid amide; compound with acetic acid

: 85234-85-1
cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Guidance literature:: With 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 8h; Ambient temperature;
DOI:10.1021/jm00357a007

Reference yield:

: 85893-46-5
(2S,4R)-1-Benzyl-4-(phenyl-propionyl-amino)-piperidine-2-carboxylic acid amide

: 85234-85-1
cis-(+/-)-1-(2-phenylethyl)-4-(N-phenylpropanamido)-piperidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10 percent Pd/C / methanol / 6 h / 25 °C

2: 71 percent / NaBH₃CN, molecular sieves (Linde 3A) / methanol / 8 h / Ambient temperature

With 3 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00357a007