(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

Base Information

Chemical Name:(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone
CAS No.:1309794-06-6
Molecular Formula:C₁₅H₁₆F₂N₂O₃
Molecular Weight:310.3
Hs Code.:

Synonyms:(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

Chemical Property:

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Technology Process of (R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

There total 6 articles about (R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: C₁₁H₈ClF₂NO₂

: 1309794-06-6
(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

Guidance literature:: With triethylamine; In dichloromethane; for 16h;

Reference yield:

: 1550-35-2
2,4-difluorobenzaldehyde

: 1309794-06-6
(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 16 h / Reflux

2.1: N-chloro-succinimide / dichloromethane; N,N-dimethyl-formamide / 16 h / Cooling with ice bath; Heating

3.1: triethylamine / isopropyl alcohol / 24 h

4.1: toluene-4-sulfonic acid; water / tetrahydrofuran / 312 h / Reflux

4.3: pH 3

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h

6.1: triethylamine / dichloromethane / 16 h

With N-chloro-succinimide; oxalyl dichloride; hydroxylamine hydrochloride; water; sodium acetate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1309794-05-5
(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)acetic acid

: 1309794-06-6
(R)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h

2: triethylamine / dichloromethane / 16 h

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;