3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester
CAS No.:161468-64-0
Molecular Formula:C₁₈H₁₉N₃O₃
Molecular Weight:325.367
Hs Code.:

Synonyms:3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

There total 3 articles about 3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 161468-63-9
1,2-Dihydro-2-oxo-3H-imidazo<4,5-c>pyridine-3-carboxylic acid 1,1-dimethylethyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 2-Benzyloxy-imidazo[4,5-c]pyridine-3-carboxylic acid tert-butyl ester

: 161468-64-0
3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 1h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo00111a014

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 161468-64-0
3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / NaH / dimethylformamide / 1.) 10 min, 2.) r.t., 2 h

2: 70 percent / DEAD, PPh₃ / tetrahydrofuran / 1 h / Ambient temperature

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a014

Reference yield:

: 7397-68-4
1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one

: 161468-64-0
3-(Phenylmethyl)-2,3-dihydro-2-oxo-1H-imidazo<4,5-c>pyridine-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / NaH / dimethylformamide / 1.) 10 min, 2.) r.t., 2 h

2: 70 percent / DEAD, PPh₃ / tetrahydrofuran / 1 h / Ambient temperature

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a014