2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

Base Information

Chemical Name:2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine
CAS No.:627488-92-0
Molecular Formula:C₁₆H₁₇ClN₂O₂S
Molecular Weight:336.842
Hs Code.:

Synonyms:2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

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Chemical Property of 2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

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Technology Process of 2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

There total 6 articles about 2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 627488-43-1
4-[[2-[(dimethylamino)methyl]phenyl]thio]-3-nitrobenzenemethanol

: 627488-92-0
2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

Guidance literature:: With thionyl chloride; triethylamine; In chloroform; for 2h; Heating;
DOI:10.1021/jm0400808

Reference yield:

: 30565-72-1
4-chloro-3-nitrobenzyl acetate

: 627488-92-0
2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / Cu; K₂CO₃ / dimethylformamide / 65 °C

2: SOCl₂ / 70 °C

3: K₂CO₃ / tetrahydrofuran / 20 °C

4: 67 percent / BH₃*THF / tetrahydrofuran / 70 °C

5: 66 percent / Et₃N; SOCl₂ / CHCl₃ / 2 h / Heating

With thionyl chloride; borane-THF; copper; potassium carbonate; triethylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0400808

Reference yield:

: 147-93-3
Thiosalicylic acid

: 627488-92-0
2-[[4-(chloromethyl)-2-nitrophenyl]thio]-N,N-dimethylbenzenemethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / Cu; K₂CO₃ / dimethylformamide / 65 °C

2: SOCl₂ / 70 °C

3: K₂CO₃ / tetrahydrofuran / 20 °C

4: 67 percent / BH₃*THF / tetrahydrofuran / 70 °C

5: 66 percent / Et₃N; SOCl₂ / CHCl₃ / 2 h / Heating

With thionyl chloride; borane-THF; copper; potassium carbonate; triethylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm0400808