(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Base Information

Chemical Name:(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol
CAS No.:81801-11-8
Molecular Formula:C₁₄H₂₀O₄S
Molecular Weight:284.376
Hs Code.:

Synonyms:(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Suppliers and Price of (1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

There total 3 articles about (1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80581-19-7
((2S,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)oxiran-2-yl)methanol

: 108-98-5
thiophenol

: 81801-11-8
(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Guidance literature:: With sodium hydroxide; In tert-butyl alcohol; at 100 ℃; for 3h;
DOI:10.1021/ja00376a050

Reference yield:

: 146986-66-5
(S)-4,5-isopropylidenedioxy-2-pentenol

: 81801-11-8
(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: Ti(O-i-Pr)4, (+)-DET, TBHP / CH₂Cl₂ / 15 h / -20 °C

2: NaOH / 2-methyl-propan-2-ol / 3 h / 100 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium hydroxide; diethyl (2R,3R)-tartrate; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00376a050

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 81801-11-8
(1R,2S)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-phenylsulfanyl-propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) NaBH₄ / 1.) toluene, 0 deg C, 39 h, 2.) MeOH, -40 deg C, 10 min

2: Ti(O-i-Pr)4, (+)-DET, TBHP / CH₂Cl₂ / 15 h / -20 °C

3: NaOH / 2-methyl-propan-2-ol / 3 h / 100 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium hydroxide; sodium tetrahydroborate; diethyl (2R,3R)-tartrate; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00376a050