(S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Base Information

Chemical Name:(S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate
CAS No.:1197191-37-9
Molecular Formula:C₂₈H₃₂F₃N₅O₇S
Molecular Weight:639.653
Hs Code.:

Synonyms:(S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

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Chemical Property of (S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

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Technology Process of (S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

There total 1 articles about (S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1197191-97-1
4-(pyrimidin-2-ylamino)butan-1-ol

: 432515-23-6
t-butyl (S)-3-(4-hydroxy-3-nitrophenyl)-2-(3-trifluoromethyl-1-benzenesulfonylamino)-propionate

: 1197191-37-9
(S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm901133z

Reference yield: 95.0%

: 1197191-37-9
(S)-t-butyl 3-(3-nitro-4-(4-(pyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propionate

: 1197191-59-5
(S)-3-(3-amino-4-(4-(1,4,5,6-tetrahydropyrimidin-2-ylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoic acid

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; In acetic acid; at 20 ℃; for 2h; under 2327.23 Torr;
DOI:10.1021/jm901133z