(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

Chemical Name:(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:509078-49-3
Molecular Formula:C₁₆H₁₇N₃O₂
Molecular Weight:283.33
Hs Code.:

Synonyms:(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Chemical Property of (3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Technology Process of (3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

There total 1 articles about (3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 608146-30-1
N-tert-butyloxycarbonyl-L-prolyl-L-tryptophan methyl ester

: 38136-70-8,41222-71-3,67889-75-2,73136-47-7
brevianamide F

: 509078-49-3
(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: at 200 ℃; for 4h;
DOI:10.1021/jo034703l

Reference yield: 42.0%

: 455-13-0
4-Iodobenzotrifluoride

: 509078-49-3
(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: 1454306-41-2
(3R,8aS)-3-((2-(4-(trifluoromethyl)phenyl)-1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: With silver tetrafluoroborate; ortho-nitrobenzoic acid; palladium diacetate; at 80 ℃; for 0.25h; Microwave irradiation; Inert atmosphere;
DOI:10.1039/c3md20353k

Reference yield:

: 763-10-0
geranyl diphosphate

: 509078-49-3
(3R,8aS)-3-((1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: C₂₆H₃₃N₃O₂

Guidance literature:: With prenyltransferase BrePT mutant I₃₃₇G from Aspergillus terreus; calcium chloride; In dimethyl sulfoxide; glycerol; at 37 ℃; for 2h; pH=7.5; Enzymatic reaction;
DOI:10.1021/acs.orglett.8b03124