6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

Base Information

Chemical Name:6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride
CAS No.:1185249-09-5
Molecular Formula:C₁₉H₁₇F₄N₃O*ClH
Molecular Weight:415.818
Hs Code.:

Synonyms:6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

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Chemical Property of 6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

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Technology Process of 6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

There total 5 articles about 6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1208242-23-2
C₂₄H₂₅F₄N₃O₃

: 1185249-09-5
6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran;
DOI:10.1021/ja902140m

Reference yield:

: 1185249-11-9
4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)nitrobenzene

: 1185249-09-5
6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; tin(ll) chloride / tetrahydrofuran; water / 3.5 h / 20 °C

2: pyridine; trichlorophosphate / 11 h / -20 - 20 °C

3: hydrogenchloride / tetrahydrofuran

With pyridine; hydrogenchloride; tin(ll) chloride; trichlorophosphate; In tetrahydrofuran; water;
DOI:10.1021/ja902140m

Reference yield:

: 1185249-12-0
4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)aniline

: 1185249-09-5
6-aminohexanoic acid [4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)phenyl]amide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / 11 h / -20 - 20 °C

2: hydrogenchloride / tetrahydrofuran

With pyridine; hydrogenchloride; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/ja902140m