(-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol

Base Information

• Chemical Name: (-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol
• CAS No.: 658080-75-2
• Molecular Formula: C₁₉H₂₃FINO₂
• Molecular Weight: 443.3

Synonyms:(-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol

Chemical Property of (-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol

Chemical Property:

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Technology Process of (-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol

There total 1 articles about (-)-4-iodo-α¹-(4-fluorophenyl)-α¹-[3-(dimethylamino)propyl]-1,2-benzenedimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-4-iodo-α1-(4-fluorophenyl)-α1-[3-(dimethylamino)propyl]-1,2-benzenedimethanol, hemi (+)-di-p-toluoyltartaric acid → (-)-4-iodo-α1-(4-fluorophenyl)-α1-[3-(dimethylamino)propyl]-1,2-benzenedimethanol (658080-75-2)

Guidance literature:

With sodium hydroxide; In water; at 25 - 30 ℃; for 1h;

Reference yield:

(-)-4-iodo-α1-(4-fluorophenyl)-α1-[3-(dimethylamino)propyl]-1,2-benzenedimethanol (658080-75-2) → (S)-{3-[5-iodo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl]propyl}dimethylamine (878655-30-2)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In toluene; at -5 - 0 ℃; for 4h;

Downstream raw materials:

(S)-{3-[5-iodo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl]propyl}dimethylamine

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