3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester
CAS No.:129150-71-6
Molecular Formula:C₂₃H₂₉NO₅
Molecular Weight:399.487
Hs Code.:

Synonyms:3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Suppliers and Price of 3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

There total 6 articles about 3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 129150-69-2
(E)-3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-acrylic acid methyl ester

: 129150-71-6
3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 3h; under 2280 Torr;
DOI:10.1021/jo00311a019

Reference yield:

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 129150-71-6
3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaH, n-Bu₄NI / dimethylformamide / 10 h / 25 °C

2: Et₃N, DPPA / 8 h / 85 °C

3: H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C / 2280 Torr

5: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

With diphenyl-phosphinic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a019

Reference yield:

: 57668-34-5
3-(3-(benzyloxy)phenyl)propanoic acid

: 129150-71-6
3-{4-[3-(2-tert-Butoxycarbonylamino-ethyl)-phenoxy]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, DPPA / 8 h / 85 °C

2: H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C / 2280 Torr

4: 97 percent / H₂ / 10percent Pd/C / methanol / 3 h / 25 °C / 2280 Torr

With diphenyl-phosphinic acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jo00311a019