benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

Base Information

Chemical Name:benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate
CAS No.:883559-77-1
Molecular Formula:C₃₀H₄₁NO₅
Molecular Weight:495.659
Hs Code.:

Synonyms:benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

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Chemical Property of benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

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Technology Process of benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

There total 7 articles about benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 883559-76-0
(4Z)-(6R)-6-benzyloxycarbonylaminonon-4-enal

: 116652-75-6
(R)-1-(benzyloxy)-2-methylpentan-3-one

: 883559-77-1
benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

Guidance literature:: (R)-1-(benzyloxy)-2-methylpentan-3-one; With dicyclohexylboron chloride; triethylamine; In diethyl ether; hexane; at 0 ℃; for 2h;

(4Z)-(6R)-6-benzyloxycarbonylaminonon-4-enal; In diethyl ether; at -78 - -20 ℃;

With dihydrogen peroxide; In methanol; diethyl ether; water; at 20 ℃; for 3h; pH=7;
DOI:10.1016/j.tet.2006.01.005

Reference yield:

: 883559-74-8
(R)-2-benzyloxycarbonylaminopentanal

: 883559-77-1
benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium bistrimethylsilylamide / tetrahydrofuran / 1 h / 0 °C

1.2: 78 percent / tetrahydrofuran / 1 h / 0 °C

2.1: 91 percent / DIBAL-H / toluene / 2 h / -78 °C

3.1: Et₃N; dicyclohexylboron chloride / hexane; diethyl ether / 2 h / 0 °C

3.2: diethyl ether / -78 - -20 °C

3.3: 85 percent / hydrogen peroxide / H₂O; diethyl ether; methanol / 3 h / 20 °C / pH 7

With dicyclohexylboron chloride; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; toluene; 1.2: Wittig reaction;
DOI:10.1016/j.tet.2006.01.005

Reference yield:

: 883559-75-9
ethyl (4Z)-(6R)-6-benzyloxycarbonylaminonon-4-enoate

: 883559-77-1
benzyl (1R,2Z,6R,7R,9R)-(10-benzyloxy-6-hydroxy-7,9-dimethyl-8-oxo-1-propyl-dec-2-enyl)-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / DIBAL-H / toluene / 2 h / -78 °C

2.1: Et₃N; dicyclohexylboron chloride / hexane; diethyl ether / 2 h / 0 °C

2.2: diethyl ether / -78 - -20 °C

2.3: 85 percent / hydrogen peroxide / H₂O; diethyl ether; methanol / 3 h / 20 °C / pH 7

With dicyclohexylboron chloride; diisobutylaluminium hydride; triethylamine; In diethyl ether; hexane; toluene;
DOI:10.1016/j.tet.2006.01.005