4-Chloro-2,3-difluoropyridine

Base Information

Chemical Name:4-Chloro-2,3-difluoropyridine
CAS No.:851178-99-9
Molecular Formula:C5H2ClF2N
Molecular Weight:149.525886
Hs Code.:2933399090
European Community (EC) Number:887-041-5
DSSTox Substance ID:DTXSID50466435
Wikidata:Q82292999
Mol file:851178-99-9.mol

Synonyms:4-Chloro-2,3-difluoropyridine;851178-99-9;2,3-Difluoro-4-chloropyridine;4-chloro-2,3-difluoro-pyridine;MFCD09031173;Pyridine, 4-chloro-2,3-difluoro-;chlorodifluoropyridine;SCHEMBL6347182;DTXSID50466435;AKOS006290077;SB52858;AS-59735;SY286784;AM20061541;CS-0173728;FT-0653234;EN300-104579;I11282;A841217;J-514918

Suppliers and Price of 4-Chloro-2,3-difluoropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2,3-Difluoro-4-chloropyridine 95+%
5g
$ 931.00

Crysdot
2,3-Difluoro-4-chloropyridine 95+%
1g
$ 344.00

Chemenu
4-Chloro-2,3-difluoropyridine 95%
1g
$ 636.00

American Custom Chemicals Corporation
4-CHLORO-2,3-DIFLUOROPYRIDINE 95.00%
10G
$ 1334.03

Alichem
4-Chloro-2,3-difluoropyridine
1g
$ 1029.19

AK Scientific
4-Chloro-2,3-difluoropyridine
5g
$ 1651.00

AK Scientific
4-Chloro-2,3-difluoropyridine
1g
$ 784.00

Total 32 raw suppliers

Chemical Property of 4-Chloro-2,3-difluoropyridine

Chemical Property:

Vapor Pressure:5.001mmHg at 25°C
Melting Point:-25--23℃
Refractive Index:1.4726 (589.3 nm 20℃)
Boiling Point:149.964 °C at 760 mmHg
PKA:-0.47±0.10(Predicted)
Flash Point:44.497 °C
PSA：12.89000
Density:1.451 g/cm³
LogP:2.01320
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:148.9843831
Heavy Atom Count:9
Complexity:101

Purity/Quality:

97% ^*data from raw suppliers

2,3-Difluoro-4-chloropyridine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C(=C1Cl)F)F

Technology Process of 4-Chloro-2,3-difluoropyridine

There total 2 articles about 4-Chloro-2,3-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1513-66-2
2,3-difluoropyridine

: 851178-99-9
4-chloro-2,3-difluoropyridine

Guidance literature:: 2,3-difluoropyridine; With n-butyllithium; In tetrahydrofuran; hexane;

With 1,1,2-Trichloro-1,2,2-trifluoroethane; In tetrahydrofuran; hexane;
DOI:10.1002/chem.200400837

Reference yield:

: 89402-43-7
5-chloro-2,3-difluoropyridine

: 851178-99-9
4-chloro-2,3-difluoropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / HCOONH₄; aq. AcOH / Pd/C / 6 h / 25 °C

2.1: BuLi / tetrahydrofuran; hexane

2.2: 81 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane

With n-butyllithium; ammonium formate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; hexane;
DOI:10.1002/chem.200400837

Reference yield:

: 851178-99-9
4-chloro-2,3-difluoropyridine

: 82878-63-5
3,4-difluoropyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C

2.1: i-Pr₂NH; BuLi / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 82 percent / tetrahydrofuran; hexane / 1 h / -75 °C

3.1: 96 percent / hydrazine monohydrate / tetrahydrofuran / 20 h / 50 °C

4.1: 72 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C

5.1: 60 percent / MnO₂ / octan-1-ol / 15 - 25 °C

With manganese(IV) oxide; potassium fluoride; n-butyllithium; tetrabutyl ammonium fluoride; tetramethlyammonium chloride; hydrazine hydrate; diisopropylamine; In tetrahydrofuran; octanol; hexane; dimethyl sulfoxide;
DOI:10.1002/chem.200400837