tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate
CAS No.:1372187-00-2
Molecular Formula:C₂₂H₃₃Cl₂N₃O₇S
Molecular Weight:554.492
Hs Code.:

Synonyms:tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

There total 12 articles about tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372186-96-3
tert-butyl (6R,7R)-6-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 352275-00-4,872496-91-8
(tert-butoxycarbonyl)-((4-(dimethyliminio)pyridin-1(4H)-yl)sulfonyl)amide

: 1372187-00-2
tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: In acetonitrile; at 10 - 35 ℃; for 12h;

Reference yield:

: (1RS,2SR)-3-(benzylamino)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-(3,4-dichlorophenyl)propan-1-ol

: 1372187-00-2
tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

2.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

3.2: 2 h / -78 - 35 °C

4.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

4.2: 18 h / 80 °C

4.3: 2 h / 35 °C / Cooling with ice

5.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

6.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

7.1: sodium azide / N,N-dimethyl-formamide / 70 °C

8.1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

9.1: acetonitrile / 12 h / 10 - 35 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; water; triethylamine; triphenylphosphine; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetonitrile; 8.1: Staudinger Reaction;

Reference yield:

: methyl (2RS,3RS)-2-[(benzylamino)methyl]-3-(3,4-dichlorophenyl)-3-hydroxypropanoate

: 1372187-00-2
tert-butyl (6S,7R)-6-({[(tert-butoxycarbonyl)sulfamoyl]amino}methyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

1.2: 0.5 h

2.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

4.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

5.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

5.2: 2 h / -78 - 35 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

6.2: 18 h / 80 °C

6.3: 2 h / 35 °C / Cooling with ice

7.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

8.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

9.1: sodium azide / N,N-dimethyl-formamide / 70 °C

10.1: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

11.1: acetonitrile / 12 h / 10 - 35 °C

With 1H-imidazole; aluminum (III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; water; triethylamine; triphenylphosphine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetonitrile; 10.1: Staudinger Reaction;