5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

Base Information

Chemical Name:5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide
CAS No.:1449785-85-6
Molecular Formula:C₁₄H₈F₃N₅O₂S₂
Molecular Weight:399.377
Hs Code.:

Synonyms:5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

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Chemical Property of 5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

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Technology Process of 5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

There total 2 articles about 5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449785-87-8
4-azido-2-(trifluoromethyl)benzonitrile

: 850340-82-8
5-ethynylthiophene-2-sulfonamide

: 1449785-85-6
5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

Guidance literature:: 4-azido-2-(trifluoromethyl)benzonitrile; 5-ethynylthiophene-2-sulfonamide; With copper(ll) sulfate pentahydrate; In water; tert-butyl alcohol; at 20 ℃; for 0.0833333h;

With sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 0.25h;

With acetic acid; In water; tert-butyl alcohol; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.06.041

Reference yield:

: N-[(dimethylamino)methylidene]-5-[2-(trimethylsilyl)ethynyl]thiophene-2-sulfonamide

: 1449785-85-6
5-{1-[4-cyano-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2.1: copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 0.08 h / 20 °C

2.2: 0.25 h / 20 °C

2.3: 0.5 h / 20 °C

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2013.06.041