2,3-PYRIDINEDIAMINE, 6-CHLORO-N2-METHYL-

Base Information

• Chemical Name: 2,3-PYRIDINEDIAMINE, 6-CHLORO-N2-METHYL-
• CAS No.: 89660-14-0
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.603
• Hs Code.: 2933399090
• Mol file: 89660-14-0.mol

Synonyms:6-Chloro-N2-methylpyridine-2,3-diamine;2-methylamino-3-amino-6-chloropyridine;2,3-Pyridinediamine,6-chloro-N2-methyl;

Chemical Property of 2,3-PYRIDINEDIAMINE, 6-CHLORO-N2-METHYL-

Chemical Property:

• PSA: 50.94000
• LogP: 2.01310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-N-methylpyridine-2,3-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-PYRIDINEDIAMINE, 6-CHLORO-N2-METHYL-

There total 2 articles about 2,3-PYRIDINEDIAMINE, 6-CHLORO-N2-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-chloro-N-methyl-3-nitropyridin-2-amine (33742-70-0) → 6-chloro-N2-methylpyridine-2,3-diamine (89660-14-0)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In water; for 18h; Reflux;

DOI:10.1016/j.bmcl.2016.01.021

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 6-chloro-N2-methylpyridine-2,3-diamine (89660-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67.8 percent / H₂O; ethanol / 4 h / 5 - 10 °C

2: 37percent HCl, zinc powder / acetic acid / 0.5 h / 8 - 10 °C

With hydrogenchloride; zinc; In ethanol; water; acetic acid;

Reference yield:

6-chloro-N2-methylpyridine-2,3-diamine (89660-14-0) → 2-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile (1352426-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 80 °C

2: sodium hydrogencarbonate / Pd(t-Bu₃P)2 / 1,4-dioxane / 0.2 h / 100 °C / Inert atmosphere; Microwave irradiation

With sodium hydrogencarbonate; Pd(t-Bu₃P)2; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

6-chloro-N-methyl-3-nitropyridin-2-amine

2,6-dicholoro-3-nitropyridine

Downstream raw materials:

5-chloro-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

1-phenyl-3-methyl-5-chloroimidazo<4,5-b>pyridin-2-one

2-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile

2-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile

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