(S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

Base Information

Chemical Name:(S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate
CAS No.:1382936-13-1
Molecular Formula:C₁₉H₂₃F₂N₃O₄
Molecular Weight:395.406
Hs Code.:

Synonyms:(S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

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Technology Process of (S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

There total 2 articles about (S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 220717-54-4
4-<2-<(S)-1-tert-butyloxycarbonylamino-2-methylpropyl>>-oxazole carboxylic acid

: 3863-11-4
3,4-difluoroaniline

: 1382936-13-1
(S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 20.5h;
DOI:10.1007/s00044-012-0141-8

Reference yield:

: 158068-97-4
2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole

: 1382936-13-1
(S)-tert-butyl [4-(3,4-difluorophenylcarbamoyl)oxazol-2-yl]-2-methylpropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; water / 16 h / 20 °C

2: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 20.5 h / 0 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water;
DOI:10.1007/s00044-012-0141-8