4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

Base Information

Chemical Name:4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate
CAS No.:1621273-29-7
Molecular Formula:C₂HF₃O₂*C₂₁H₁₈F₃N₃O
Molecular Weight:499.413
Hs Code.:

Synonyms:4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

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Chemical Property of 4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

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Technology Process of 4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

There total 6 articles about 4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621273-27-5
5-methyl-3-(3-(trifluoromethyl)phenylamino)cyclopent-2-enone

: [benzenesulfonyl-(4-cyano-phenyl)-methyl]-carbamic acid tert-butyl ester

: 1621273-29-7
4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; 2-methyltetrahydrofuran / 0.33 h

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; sodium hydride; In 2-methyltetrahydrofuran; 1,4-dioxane; mineral oil;

Reference yield:

: C₂₆H₂₆F₃N₃O₃

: 76-05-1
trifluoroacetic acid

: 1621273-29-7
4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

Guidance literature:: C₂₆H₂₆F₃N₃O₃; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 886844-09-3
3-benzyloxycyclopent-2-en-1-one

: 1621273-29-7
4-(amino(4-methyl-5-oxo-2-(3-(trifluoromethyl)phenylamino)cyclopent-1-enyl)-methyl)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / Cooling with acetone-dry ice

1.2: 20 °C

2.1: 10% Pd/C; hydrogen / toluene / 9 h / 20 °C / 2550.26 Torr

3.1: ytterbium(III) triflate / 20 °C

4.1: sodium hydride / mineral oil; 2-methyltetrahydrofuran / 0.33 h

4.2: 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; 10% Pd/C; hydrogen; sodium hydride; ytterbium(III) triflate; lithium diisopropyl amide; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; toluene; mineral oil;