4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

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Chemical Name:4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide
CAS No.:361392-71-4
Molecular Formula:C₂₄H₂₄BrN₅O₂
Molecular Weight:494.391
Hs Code.:

Synonyms:4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

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Chemical Property of 4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

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Technology Process of 4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

There total 3 articles about 4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 361392-71-4
4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cs₂CO₃ / acetone / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: hexane; tetrahydrofuran / -78 °C

3.1: N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

4.1: pyridine / tetrahydrofuran / 1 h

With 4-methyl-morpholine; pyridine; n-butyllithium; caesium carbonate; In tetrahydrofuran; hexane; acetone;
DOI:10.1021/jm0005555

Reference yield:

: (E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylimidoformamide

: 361392-71-4
4-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / HOAc / 1 h / Heating

2: 89 percent / HOAc; Fe / ethanol / 3 h / Heating

3: pyridine / tetrahydrofuran / 1 h

With pyridine; iron; acetic acid; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0005555