(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Base Information

Chemical Name:(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline
CAS No.:246521-92-6
Molecular Formula:C₃₀H₃₀N₂O₄
Molecular Weight:482.579
Hs Code.:

Synonyms:(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Suppliers and Price of (4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

There total 6 articles about (4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 246521-91-5
(4R,5R)-4-(benzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

: 106-95-6
allyl bromide

: 246521-92-6
(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ol990705+

Reference yield:

: (4R)-3-[4-(Benzyloxy)benzoyl]-4-[(tert-Butyldimethylsilanoxy)methyl]-5-vinyl-1,3-oxazolidine-2-one

: 246521-92-6
(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / bis(diphenylphosphino)propane / Pd₂(dba)3CHCl₃ / tetrahydrofuran / 12 h / 35 °C

2: 83 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

3: 88 percent / Ph₃P; DPPA; DEAD / 5 h / 20 °C

4: Ph₃P; H₂O / tetrahydrofuran / 12 h / 20 °C

5: 232 mg / Et₃N / 3 h

6: 87 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 20 °C

With bis(diphenylphosphino)propane; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; water; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 3: Mitsunobu reaction;
DOI:10.1021/ol990705+

Reference yield:

: 246521-88-0
(4R,5R)-2-[4-(benzyloxy)phenyl]-4-[(tert-butyldimethylsilanyloxy)methyl]-5-vinyl-1,3-oxazoline

: 246521-92-6
(4R,5R)-4-(allylbenzyloxycarbonylaminomethyl)-2-[4-(benzyloxy)phenyl]-5-vinyl-1,3-oxazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

2: 88 percent / Ph₃P; DPPA; DEAD / 5 h / 20 °C

3: Ph₃P; H₂O / tetrahydrofuran / 12 h / 20 °C

4: 232 mg / Et₃N / 3 h

5: 87 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 20 °C

With diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; water; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1021/ol990705+