Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Base Information

Chemical Name:Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate
CAS No.:572920-44-6
Molecular Formula:C13H12 Cl N3 O3
Molecular Weight:293.71
Hs Code.:
DSSTox Substance ID:DTXSID70478338
Wikidata:Q82311667

Synonyms:572920-44-6;ETHYL 5-CHLORO-3-(4-METHOXYPHENYL)-1,2,4-TRIAZINE-6-CARBOXYLATE;5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylic acid ethyl ester;DTXSID70478338;1,2,4-Triazine-6-carboxylicacid,5-chloro-3-(4-methoxyphenyl)-,ethyl ester;A831372

Suppliers and Price of Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:293.0567189
Heavy Atom Count:20
Complexity:324

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(N=N1)C2=CC=C(C=C2)OC)Cl

Technology Process of Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

There total 4 articles about Ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 572920-40-2
ethyl 3-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylate

: 572920-44-6
ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Guidance literature:: With phosphorus pentachloride; In toluene; for 25h;
DOI:10.1135/cccc20030965

Reference yield:

: 62230-46-0
4-methoxybenzohydrazonamide

: 572920-44-6
ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / propan-2-ol / 18 h / 20 °C

2: 68 percent / PCl₅ / toluene / 25 h

With phosphorus pentachloride; In isopropyl alcohol; toluene;
DOI:10.1135/cccc20030965

Reference yield:

: 874-90-8
4-methoxybenzonitrile

: 572920-44-6
ethyl 5-chloro-3-(4-methoxyphenyl)-1,2,4-triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl / 0 - 20 °C

1.2: 62 percent / aq. N₂H₄*H₂O / ethanol / 48 h / 0 °C

2.1: 66 percent / propan-2-ol / 18 h / 20 °C

3.1: 68 percent / PCl₅ / toluene / 25 h

With hydrogenchloride; phosphorus pentachloride; In isopropyl alcohol; toluene;
DOI:10.1135/cccc20030965