9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

Base Information

Chemical Name:9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione
CAS No.:684284-62-6
Molecular Formula:C₃₁H₂₁FN₂O₄
Molecular Weight:504.517
Hs Code.:

9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-<i>g</i>]quinoline-6,8-dione

Synonyms:9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

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Chemical Property of 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

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Technology Process of 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

There total 3 articles about 9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 684284-61-5
carbonic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester ethyl ester

: 684284-62-6
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

Guidance literature:: With dmap; potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-29-5
7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

: 684284-62-6
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

2: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

3: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

With dmap; sodium hydroxide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016

Reference yield:

: 684284-30-8
carbonic acid ethyl ester 7-(4-fluoro-benzyl)-9-hydroxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester

: 684284-62-6
9-benzhydryloxy-7-(4-fluoro-benzyl)-5-hydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1,2-dichloro-ethane / 3 h / 70 °C

2: 100 percent / K₂CO₃; 4-dimethylaminopyridine / tetrahydrofuran; H₂O / 12 h / 20 °C

With dmap; potassium carbonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.05.016