4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

Chemical Name:4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.:644982-20-7
Molecular Formula:C18H25 N O4
Molecular Weight:319.39500
Hs Code.:2933399990
Mol file:644982-20-7.mol

Synonyms:4-(Carboxymethyl)-4-phenylpiperidine-1-carboxylicacid tert-butyl ester

Suppliers and Price of 4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-[1-(tert-Butoxycarbonyl)-4-phenylpiperidin-4-yl]acetic acid
1 g
$ 1016.00

Matrix Scientific
2-[1-(tert-Butoxycarbonyl)-4-phenyl-4-piperidinyl]acetic acid
10g
$ 1764.00

Matrix Scientific
2-[1-(tert-Butoxycarbonyl)-4-phenyl-4-piperidinyl]acetic acid
5g
$ 1260.00

Matrix Scientific
2-[1-(tert-Butoxycarbonyl)-4-phenyl-4-piperidinyl]acetic acid
1g
$ 540.00

Crysdot
2-(1-(tert-Butoxycarbonyl)-4-phenylpiperidin-4-yl)aceticacid 95+%
1g
$ 705.00

Apolloscientific
2-[1-(tert-Butoxycarbonyl)-4-phenylpiperidin-4-yl]aceticacid
1g
$ 921.00

Total 6 raw suppliers

Chemical Property of 4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

PSA：66.84000
LogP:3.36790

Purity/Quality:

97% ^*data from raw suppliers

2-[1-(tert-Butoxycarbonyl)-4-phenylpiperidin-4-yl]acetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 4-CARBOXYMETHYL-4-PHENYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 644982-19-4
4-(1-cyano-1-ethoxycarbonyl-methyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 644982-20-7
4-carboxymethyl-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-(1-cyano-1-ethoxycarbonyl-methyl)-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester; With sulfuric acid; water; acetic acid; at 140 ℃; for 12h;

di-tert-butyl dicarbonate; With sodium hydroxide; In water; at 20 ℃; for 48h; pH=8;

With hydrogenchloride; In water; at 0 ℃; pH=6 - 7;

Reference yield:

: 158144-79-7
tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate

: 644982-20-7
4-carboxymethyl-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate; With diisobutylaluminium hydride; In toluene; at -78 - -35 ℃; for 2.5h; Inert atmosphere;

With sodium chlorite; CH₂O₄^(1-)*Na⁽¹⁺⁾; water; In tert-butyl alcohol; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200279v

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 644982-20-7
4-carboxymethyl-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 2.5 h / -78 - -35 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm200279v