tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate
CAS No.:1339892-12-4
Molecular Formula:C₂₂H₂₆N₄O₃
Molecular Weight:394.473
Hs Code.:

Synonyms:tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 956136-85-9
4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

: 56817-09-5
7-chloro-5H,6H-imidazo[1,2-c]pyrimidin-5-one

: 1339892-12-4
tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

Guidance literature:: 4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester; 7-chloro-5H,6H-imidazo[1,2-c]pyrimidin-5-one; With potassium phosphate; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In isopropyl alcohol; at 90 ℃; for 54h; Inert atmosphere;

With potassium hydroxide; In methanol;

With hydrogenchloride; In methanol; water; pH=9;

Reference yield:

: 769944-78-7
tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate

: 1339892-12-4
tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 1.5 h / 110 °C / Inert atmosphere

2.1: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / isopropyl alcohol / 54 h / 90 °C / Inert atmosphere

2.3: pH 9

With potassium phosphate; water; triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 1339891-11-0
7-chloro-5-(methylsulfanyl)imidazo[1,2-c]pyrimidine hydrochloride

: 1339892-12-4
tert-butyl 4-(4-(5-hydroxyimidazo[1,2-c]pyrimidin-7-yl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / methanol / 2 h / Reflux

1.2: pH 6 - 7

2.1: potassium phosphate; water / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / isopropyl alcohol / 54 h / 90 °C / Inert atmosphere

2.3: pH 9

With potassium phosphate; water; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In methanol; isopropyl alcohol;