4-(isoquinolin-1-yl)-N,N-dimethylaniline

Base Information

Chemical Name:4-(isoquinolin-1-yl)-N,N-dimethylaniline
CAS No.:32564-93-5
Molecular Formula:C₁₇H₁₆N₂
Molecular Weight:248.327
Hs Code.:

Synonyms:4-(isoquinolin-1-yl)-N,N-dimethylaniline

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Chemical Property of 4-(isoquinolin-1-yl)-N,N-dimethylaniline

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Technology Process of 4-(isoquinolin-1-yl)-N,N-dimethylaniline

There total 5 articles about 4-(isoquinolin-1-yl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 19493-44-8
1-chloroisoquinoline

: 28611-39-4
4-(dimethylamino)benzene-boronic acid

: 32564-93-5
4-(isoquinolin-1-yl)-N,N-dimethylaniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 20h; Inert atmosphere; Sealed tube;
DOI:10.1007/s12039-017-1350-y

Reference yield: 82.0%

: 586-77-6
4-bromo-N,N-dimethylaniline

: sodium isoquinoline-1-sulfinate

: 32564-93-5
4-(isoquinolin-1-yl)-N,N-dimethylaniline

Guidance literature:: 4-bromo-N,N-dimethylaniline; With magnesium; In tetrahydrofuran; at 80 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

sodium isoquinoline-1-sulfinate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.8b03918

Reference yield:

: 4702-25-4
2-mercaptoisoquinoline

: 32564-93-5
4-(isoquinolin-1-yl)-N,N-dimethylaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; dihydrogen peroxide / water; ethanol / 20 °C / Schlenk technique; Inert atmosphere

2.1: magnesium / tetrahydrofuran / 0.5 h / 80 °C / Inert atmosphere; Schlenk technique

2.2: 12 h / 20 °C / Inert atmosphere; Schlenk technique

With dihydrogen peroxide; magnesium; sodium hydroxide; In tetrahydrofuran; ethanol; water; 2.1: |Grignard Reaction;
DOI:10.1021/acs.orglett.8b03918