ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate

Base Information

• Chemical Name: ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate
• CAS No.: 871797-58-9
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 871797-58-9.mol

Synonyms:ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate

Chemical Property of ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate

There total 11 articles about ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-phenyl-propionaldehyde (104-53-0) + ethyl (E)-2-(p-methoxyphenylimino)acetate (115276-75-0,124156-21-4,120419-96-7) → ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate (871797-58-9)

Guidance literature:

With (S)-3-CF₃SO₂NH-2,2'-CH₂-NH-CH₂-1,1'-binaphthalene; In 1,4-dioxane; at 20 ℃; for 4h;

DOI:10.1021/ja056008w

Reference yield: 66.0%

3-phenyl-propionaldehyde (104-53-0) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate (871797-58-9)

Guidance literature:

With 4-((3S,4S)-((((4-trifluoromethanesulfonamido)pyrrolidin-3-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)methyl polystyrene; In N,N-dimethyl-formamide; at 0 ℃; for 4h; enantioselective reaction;

DOI:10.1039/c3gc41444b

Reference yield: 63.0%

3-phenyl-propionaldehyde (104-53-0) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)-4-phenyl-butanoate (871797-58-9) + C20H23NO4

Guidance literature:

With N,N-diphenylthiourea; In N,N-dimethyl-formamide; at 50 ℃; stereoselective reaction; Flow reactor;

DOI:10.1002/adsc.201901185

upstream raw materials:

3-phenyl-propionaldehyde

ethyl (E)-2-(p-methoxyphenylimino)acetate

ethyl (4-methoxyphenylimino)acetate

2-methoxy-phenylamine