(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

Base Information

Chemical Name:(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one
CAS No.:276252-74-5
Molecular Formula:C₁₆H₂₁ClN₂O₄
Molecular Weight:340.807
Hs Code.:

Synonyms:(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

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Chemical Property of (R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

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Technology Process of (R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

There total 4 articles about (R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125948-52-9
S,S-dilactic acid diethyl ester

: 276252-74-5
(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether / 0.75 h / Heating

2: pyridine / 4 h / 0 °C

3: dioxane / 40 h / Heating

4: H₂ / Pd/C / acetic acid; methanol

With pyridine; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; acetic acid; 1: Reduction / 2: mesylation / 3: Alkylation / 4: Hydrogenolysis;
DOI:10.1016/S0957-4166(00)00011-2

Reference yield:

: 125948-51-8
(S)-2-(((S)-1-hydroxypropan-2-yl)oxy)propan-1-ol

: 276252-74-5
(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / 0 °C

2: dioxane / 40 h / Heating

3: H₂ / Pd/C / acetic acid; methanol

With pyridine; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; acetic acid; 1: mesylation / 2: Alkylation / 3: Hydrogenolysis;
DOI:10.1016/S0957-4166(00)00011-2

Reference yield:

: 276252-72-3
(2S,6S)-4-benzyl-2,6-dimethylmorpholine

: 276252-74-5
(R)-3-(4-Chloro-phenyl)-1-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-4-nitro-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / acetic acid; methanol

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; 1: Hydrogenolysis;
DOI:10.1016/S0957-4166(00)00011-2