4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester

Base Information

• Chemical Name: 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
• CAS No.: 939757-89-8
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Hs Code.: 2933990090
• Mol file: 939757-89-8.mol

Synonyms:1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid;4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester;1-(boc)-4-phenylpyrrolidine-3-carboxylic acid

Chemical Property of 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester

Chemical Property:

• Boiling Point: 441.5 °C at 760 mmHg
• PKA: 4.31±0.40(Predicted)
• Flash Point: 220.8 °C
• PSA: 66.84000
• Density: 1.196 g/cm³
• LogP: 2.65960
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester

There total 25 articles about 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(tert-butoxycarbonyl)-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (951742-86-2) → (3R,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid (951742-87-3,221142-28-5,884048-45-7,939757-89-8)

Guidance literature:

1-(tert-butoxycarbonyl)-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid; With hydrogen; triethylamine; [Ru(OAc)2((S)-(6-MeO-2-Naphthyl)-MeOBIPHEP)]; In methanol; at 80 ℃; for 42h; under 30003 Torr;

With sodium hydroxide; In methanol; tert-butyl methyl ether; water;

With hydrogenchloride; In water; at 0 ℃; pH=1; Product distribution / selectivity;

Reference yield: 91.0%

1-(tert-butoxycarbonyl)-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (951742-86-2) → (3S,4S)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid (951742-88-4,221142-28-5,884048-45-7,939757-89-8)

Guidance literature:

1-(tert-butoxycarbonyl)-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid; With hydrogen; triethylamine; [Ru(OAc)2((R)-MeOBIPHEP)]; In methanol; toluene; at 80 ℃; for 42h; under 30003 Torr;

With sodium hydroxide; In methanol; tert-butyl methyl ether; water;

With hydrogenchloride; In water; at 0 ℃; pH=1; Product distribution / selectivity;

Reference yield: 89.0%

(3S,4S)-1-pyrrolidinecarboxylic acid 3-[[[(1,1-dimethylethoxy)carbonyl]-8-quinolinylamino]carbonyl]-4-(4-phenyl)-1,1-dimethylethyl ester → (3S,4S)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid (951742-88-4,221142-28-5,884048-45-7,939757-89-8)

Guidance literature:

With water; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere; Sealed tube;

upstream raw materials:

C₁₇H₂₃NO₄

di-tert-butyl dicarbonate

cis-1-tert-butyl 3-methyl 4-phenylpyrrolidine-1,3-dicarboxylate

(4R)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one

Downstream raw materials:

C₁₂H₁₅NO₂*ClH

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