[7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester

Base Information

• Chemical Name: [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester
• CAS No.: 266347-98-2
• Molecular Formula: C₁₇H₁₇N₅O₅
• Molecular Weight: 371.352

Synonyms:[7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester

Chemical Property of [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester

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Technology Process of [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester

There total 2 articles about [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-[[[(methoxycarbonyl)amino][(methoxycarbonyl)imino]methyl]amino]-4-[[N-(ethoxycarbonyl)-N-phenyl]amino]-1H-pyrrole-2-carboxylate (266347-97-1) → [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester (266347-98-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1080/15257770008033016

Reference yield:

methyl 3-amino-4-[[N-(ethoxycarbonyl)-N-phenyl]amino]-1H-pyrrole-2-carboxylate (266348-09-8) → [7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester (266347-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / AcOH / methanol

2: 87 percent / NaOMe / methanol / 2 h / 20 °C

With sodium methylate; acetic acid; In methanol; 1: Substitution / 2: Cyclization;

DOI:10.1080/15257770008033016

Reference yield: 97.0%

[7-(ethoxycarbonyl-phenyl-amino)-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl]-carbamic acid methyl ester (266347-98-2) → (2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl-carbamic acid ethyl ester (266347-99-3)

Guidance literature:

With sodium hydroxide; In water; at 50 ℃; for 1h;

DOI:10.1080/15257770008033016

upstream raw materials:

methyl 3-[[[(methoxycarbonyl)amino][(methoxycarbonyl)imino]methyl]amino]-4-[[N-(ethoxycarbonyl)-N-phenyl]amino]-1H-pyrrole-2-carboxylate

methyl 3-amino-4-[[N-(ethoxycarbonyl)-N-phenyl]amino]-1H-pyrrole-2-carboxylate

Downstream raw materials:

(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl-carbamic acid ethyl ester

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