(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

Base Information

Chemical Name:(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile
CAS No.:860267-38-5
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:380.444
Hs Code.:

Synonyms:(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

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Technology Process of (SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

There total 1 articles about (SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 120-57-0,30024-74-9
piperonal

: 143-33-9,25596-52-5
sodium cyanide

: ((4R,5R)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amine

: 860267-38-5
(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

Guidance literature:: sodium cyanide; In methanol; at 20 ℃; for 0.333333h;

piperonal; ((4R,5R)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amine; In methanol; at 0 ℃;

With acetic acid; In methanol; at 20 ℃; for 72h;
DOI:10.1002/ejoc.200400885

Reference yield: 83.0%

: 860267-38-5
(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

: 118415-99-9
(E)-1-(benzo[d][1,3]dioxol-6-yl)but-2-en-1-one

: 860267-39-6
(2S,3S)-2,5-bis(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}-3-methyl-5-oxopentanenitrile

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -100 - -10 ℃;
DOI:10.1002/ejoc.200400885

Reference yield:

: 860267-38-5
(SR)-2-(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}acetonitrile

: 860267-40-9
(2S,3S,4S)-2,5-bis(benzo[d][1,3]dioxol-6-yl)-2-{methyl[(4R,5R)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]amino}-3,4-methyl-5-oxopentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / LDA / tetrahydrofuran; hexane / -100 - -10 °C

2.1: KDA / tetrahydrofuran; hexane / 4 h / -78 °C

2.2: 90 percent / tetrahydrofuran; hexane / -100 - -10 °C

With Diethoxy-methyl-(6-amino-hexylaminomethyl)-silan; lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.1: Michael addition;
DOI:10.1002/ejoc.200400885