6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

Base Information

Chemical Name:6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl
CAS No.:177264-41-4
Molecular Formula:C₃₂H₃₆N₂O₃Si
Molecular Weight:524.735
Hs Code.:

Synonyms:6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

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Chemical Property of 6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

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Technology Process of 6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

There total 9 articles about 6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 177264-40-3
6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-pyridine-2-carbonitrile

: 74-86-2,25067-58-7
acetylene

: 177264-41-4
6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

Guidance literature:: With (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene; at 120 ℃; for 48h; under 10640 Torr;
DOI:10.1016/0957-4166(96)00086-9

Reference yield:

: 50622-09-8
2,3-O-isopropylidene-L-threitol

: 177264-41-4
6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) sodium hydride / 1.) THF, RT, 45 min, 2.) THF, 45 min

2: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, RT, 1 h

3: NH₂OH*HCl, 10percent aq.Na₂CO₃ / methanol / 24 h

4: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 1 h

5: 94 percent / (π-cyclopentadienyl)cobalt-1,5-cyclooctadiene / toluene / 24 h / 120 °C / 10640 Torr

6: 3-chloroperbenzoic acid / CH₂Cl₂ / 24 h / Ambient temperature

7: dimethylcarbamyl chloride / CH₂Cl₂ / 5 h / Ambient temperature

8: 56 percent / (π-cyclopentadienyl)cobalt-1,5-cyclooctadiene / toluene / 48 h / 120 °C / 10640 Torr

With oxalyl dichloride; (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); hydroxylamine hydrochloride; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; N,N-Dimethylcarbamoyl chloride; In methanol; dichloromethane; toluene;
DOI:10.1016/0957-4166(96)00086-9

Reference yield:

: 136032-73-0,127251-09-6
4-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-L-threitol

: 177264-41-4
6-[(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2,2']bipyridinyl

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, RT, 1 h

2: NH₂OH*HCl, 10percent aq.Na₂CO₃ / methanol / 24 h

3: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 1 h

4: 94 percent / (π-cyclopentadienyl)cobalt-1,5-cyclooctadiene / toluene / 24 h / 120 °C / 10640 Torr

5: 3-chloroperbenzoic acid / CH₂Cl₂ / 24 h / Ambient temperature

6: dimethylcarbamyl chloride / CH₂Cl₂ / 5 h / Ambient temperature

7: 56 percent / (π-cyclopentadienyl)cobalt-1,5-cyclooctadiene / toluene / 48 h / 120 °C / 10640 Torr

With oxalyl dichloride; (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); hydroxylamine hydrochloride; sodium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; N,N-Dimethylcarbamoyl chloride; In methanol; dichloromethane; toluene;
DOI:10.1016/0957-4166(96)00086-9