[2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester
• CAS No.: 606138-92-5
• Molecular Formula: C₂₆H₃₀N₄O₆S
• Molecular Weight: 526.613

Synonyms:[2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester

Chemical Property of [2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of [2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester

There total 1 articles about [2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5-(1,1-dioxido-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid (606080-41-5) + tert-butyl [2-(aminomethyl)phenyl]acetate oxalate salt → [2-({[5-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester (606138-92-5)

Guidance literature:

With 4-methyl-morpholine; ethylenediaminetetraacetic acid; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2006.11.080

Reference yield: 71.0%

[2-({[5-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester (606138-92-5) → [2-({[5-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid (606138-93-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

DOI:10.1016/j.bmcl.2006.11.080

Reference yield:

[2-({[5-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid tert-butyl ester (606138-92-5) → 5-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 2-dimethylcarbamoylmethyl-benzylamide

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / aq. NaOH / tetrahydrofuran; methanol / 50 °C

2: BOP; TEA / dimethylformamide / 20 °C

With sodium hydroxide; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.11.080

upstream raw materials:

5-(1,1-dioxido-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid

Downstream raw materials:

[2-({[5-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-8-hydroxy-[1,6]naphthyridine-7-carbonyl]-amino}-methyl)-phenyl]-acetic acid

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