(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

Base Information

Chemical Name:(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine
CAS No.:1584641-89-3
Molecular Formula:C₂₂H₂₂ClF₅N₆O
Molecular Weight:516.901
Hs Code.:

Synonyms:(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

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Chemical Property of (S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

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Technology Process of (S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

There total 6 articles about (S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 461678-27-3
6-chloro-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine

: 3179-63-3
3-Dimethylamino-1-propanol

: 1584641-89-3
(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; mineral oil; at 60 ℃; for 2h;

Reference yield:

: 262609-07-4
diethyl (2,4,6-trifluoro-phenyl)-malonate

: 1584641-89-3
(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tributyl-amine / 1 h / 180 °C / Inert atmosphere; Sealed tube

2: 2,6-dimethylpyridine; trichlorophosphate / 16 h / 110 °C / Sealed tube

3: N,N-dimethyl-formamide / 18 h / 90 °C / Sealed tube

4: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 60 °C

With 2,6-dimethylpyridine; tributyl-amine; sodium hydride; trichlorophosphate; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 849600-51-7
4,6-dichloro-2-(pyrazin-2-yl)-5-(2,4,6-trifluorophenyl)pyrimidine

: 1584641-89-3
(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 18 h / 90 °C / Sealed tube

2: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 60 °C

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;