2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

Base Information

Chemical Name:2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene
CAS No.:180044-77-3
Molecular Formula:C₂₄H₃₂F₄O
Molecular Weight:412.511
Hs Code.:

Synonyms:2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

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Chemical Property of 2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

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Technology Process of 2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

There total 3 articles about 2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176765-67-6
4-(3-fluoro-4-trifluoromethoxy-phenyl)-cyclohexanecarbaldehyde

: 2-(trans-4-propylcyclohexyl)methyltriphenylphosphonium bromide

: 180044-77-3
2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

Guidance literature:: 2-(trans-4-propylcyclohexyl)methyltriphenylphosphonium bromide; With lithium diisopropyl amide; In tetrahydrofuran; at -10 ℃;

4-(3-fluoro-4-trifluoromethoxy-phenyl)-cyclohexanecarbaldehyde; In tetrahydrofuran; at -10 - 20 ℃;

With hydrogenchloride; MePhSO₂Na; In toluene; for 16h; Further stages.; Heating;
DOI:10.1021/ja010024l

Reference yield:

: 207462-85-9
4-(3-fluoro-4-trifluoromethoxyphenyl)cyclohexanone

: 180044-77-3
2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuOK / tetrahydrofuran / -10 - 20 °C

2.1: HCO₂H / toluene / 18 h / 20 °C

2.2: NaOH / methanol / 1 h / 20 °C

3.1: LDA / tetrahydrofuran / -10 °C

3.2: tetrahydrofuran / -10 - 20 °C

3.3: MePhSO₂Na; HCl / toluene / 16 h / Heating

With formic acid; potassium tert-butylate; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/ja010024l

Reference yield:

: 2-fluoro-4-(4-methoxymethylene-cyclohexyl)-1-trifluoromethoxy-benzene

: 180044-77-3
2-Fluoro-4-{4-[(E)-2-(4-propyl-cyclohexyl)-vinyl]-cyclohexyl}-1-trifluoromethoxy-benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCO₂H / toluene / 18 h / 20 °C

1.2: NaOH / methanol / 1 h / 20 °C

2.1: LDA / tetrahydrofuran / -10 °C

2.2: tetrahydrofuran / -10 - 20 °C

2.3: MePhSO₂Na; HCl / toluene / 16 h / Heating

With formic acid; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/ja010024l