4-(p-Phenoxyphenyl)-4-hydroxybutanol

Base Information

• Chemical Name: 4-(p-Phenoxyphenyl)-4-hydroxybutanol
• CAS No.: 52888-61-6
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 52888-61-6.mol

Synonyms:4-(p-Phenoxyphenyl)-4-hydroxybutanol

Chemical Property of 4-(p-Phenoxyphenyl)-4-hydroxybutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(p-Phenoxyphenyl)-4-hydroxybutanol

There total 3 articles about 4-(p-Phenoxyphenyl)-4-hydroxybutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(4-phenoxyphenyl)but-3-en-1-ol (1245945-55-4) → 4-(p-Phenoxyphenyl)-4-hydroxybutanol (52888-61-6)

Guidance literature:

1-(4-phenoxyphenyl)but-3-en-1-ol; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1039/c9cc04287c

Reference yield:

4-phenoxy benzaldehyde (67-36-7) → 4-(p-Phenoxyphenyl)-4-hydroxybutanol (52888-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 4 h / 0 - 20 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 - 20 °C

With dimethylsulfide borane complex; In tetrahydrofuran; diethyl ether;

DOI:10.1039/c9cc04287c

Reference yield:

→ 4-(p-Phenoxyphenyl)-4-hydroxybutanol (52888-61-6)

Guidance literature:

β-(p-Phenoxybenzoyl)propionsaeureethylester, LiBH4;

upstream raw materials:

4-phenoxy benzaldehyde

1-(4-phenoxyphenyl)but-3-en-1-ol

Downstream raw materials:

4-(4-phenoxyphenyl)butan-1-ol