6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

Base Information

Chemical Name:6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline
CAS No.:1599467-85-2
Molecular Formula:C₂₄H₁₉ClF₃N₃O₄
Molecular Weight:505.881
Hs Code.:

Synonyms:6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

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Chemical Property of 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

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Technology Process of 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

There total 7 articles about 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1354745-86-0
6-chloro-4-ethoxy-3-iodo-7-methoxy-2-methylquinoline

: 1599467-81-8
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-(trifluoromethoxy)phenoxy)pyrimidine

: 1599467-85-2
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 18h;
DOI:10.1021/jm500147k

Reference yield:

: C₁₃H₁₆ClNO₃

: 1599467-85-2
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1599467-85-2
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(2-(4-(trifluoromethoxy)phenoxy)pyrimidin-5-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; 2-Picolinic acid; potassium phosphate / dimethyl sulfoxide / 18 h / 80 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k