Technology Process of (2R)-2-benzyloxy-3-(4-benzyloxy-3-chlorophenyl)propionic acid
There total 7 articles about (2R)-2-benzyloxy-3-(4-benzyloxy-3-chlorophenyl)propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; nitrosonium tetrafluoroborate;
at -30 - 20 ℃;
for 19h;
DOI:10.1002/chem.201501370
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trifluorormethanesulfonic acid
2: lithium hydroxide / tetrahydrofuran
3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
4: palladium diacetate; potassium carbonate / acetonitrile / 24 h / 110 °C
5: nitrosonium tetrafluoroborate; pyridine / 19 h / -30 - 20 °C
With
pyridine; trifluorormethanesulfonic acid; palladium diacetate; potassium carbonate; nitrosonium tetrafluoroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201501370
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hydroxide / tetrahydrofuran
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
3: palladium diacetate; potassium carbonate / acetonitrile / 24 h / 110 °C
4: nitrosonium tetrafluoroborate; pyridine / 19 h / -30 - 20 °C
With
pyridine; palladium diacetate; potassium carbonate; nitrosonium tetrafluoroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201501370
