2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

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Chemical Name:2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide
CAS No.:1429925-42-7
Molecular Formula:C₂₃H₂₉ClIN₅O₂
Molecular Weight:569.873
Hs Code.:

Synonyms:2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

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Chemical Property of 2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

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Technology Process of 2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

There total 6 articles about 2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: (1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethanamine trihydrochloride

: 1429925-66-5
[7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 1429925-41-6
2-[(4R)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

: 1429925-42-7
2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: [7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 0.25h;

(1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethanamine trihydrochloride; In 1,4-dioxane; at 80 ℃; for 3h;

Reference yield: 20.0%

: 1429925-66-5
[7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 1401425-98-6
(2S)-1-(4-methylpiperazin-1-yl)propan-2-amine trihydrochloride

: 1429925-41-6
2-[(4R)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

: 1429925-42-7
2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: [7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 0.25h;

(2S)-1-(4-methylpiperazin-1-yl)propan-2-amine trihydrochloride; In 1,4-dioxane; at 80 ℃; for 3h;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1429925-41-6
2-[(4R)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

: 1429925-42-7
2-[(4S)-7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methyl piperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: silver trifluoroacetate; iodine / dichloromethane / 1 h / 20 °C

3.1: ethanol; lithium hydroxide; water / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1,4-dioxane / 0.25 h

4.2: 3 h / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; water; iodine; silver trifluoroacetate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water;