acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

Base Information

Chemical Name:acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester
CAS No.:1056674-78-2
Molecular Formula:C₂₈H₄₅N₃O₇
Molecular Weight:535.681
Hs Code.:

Synonyms:acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

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Chemical Property of acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

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Technology Process of acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

There total 17 articles about acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056674-73-7
C₃₅H₅₁N₃O₇

: 1056674-78-2
acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1056674-78-2
acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

1.2: 0.33 h

2.1: trifluoroacetic acid / 1 h / 20 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 72 h / 70 °C

4.1: hydrogen / palladium, 5% on calcium carbonate, poisoned with lead / ethyl acetate

5.1: dmap / dichloromethane / 0.25 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol

With 2-hydroxypyridin; dmap; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium, 5% on calcium carbonate, poisoned with lead; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1056674-45-3
(3S,5S)-5-((R)-1,2-dihydroxyethyl)-3-isopropyldihydrofuran-2(3H)-one

: 1056674-78-2
acetic acid (1S,3S)-3-((S)-1-benzylcarbamoyl-2-methylpropylcarbamoyl)-1-((S)-1-tert-butoxycarbonylamino-2-hydroxy-ethyl)-4-methylpentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: di(n-butyl)tin oxide / toluene / 4 h / Heating / reflux

1.2: 22 h / 90 °C

2.1: pyridine / dichloromethane / 0.25 - 0.5 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 60 °C

4.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 72 h / 70 °C

5.1: hydrogen / palladium, 5% on calcium carbonate, poisoned with lead / ethyl acetate

6.1: dmap / dichloromethane / 0.25 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol

With pyridine; 2-hydroxypyridin; dmap; sodium azide; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; palladium, 5% on calcium carbonate, poisoned with lead; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;