α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Base Information

Chemical Name:α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol
CAS No.:120098-66-0
Molecular Formula:C₃₀H₃₁FN₂O
Molecular Weight:454.587
Hs Code.:

Synonyms:α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

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Technology Process of α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

There total 3 articles about α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₁₂H₁₆ClMgN

: 120098-73-9
1-<(2-fluorophenyl)phenylmethyl>pyrrole-2-carboxaldehyde

: 120098-66-0
α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: In tetrahydrofuran; diethyl ether; for 1h; Heating;
DOI:10.1002/jhet.5570300132

Reference yield:

: 55095-24-4
α-(2-fluorophenyl)benzenemethanamine

: 120098-66-0
α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / acetic acid / 1.5 h / Heating

2: 1.) phosphorus oxychloride, 2.) sodium acetate trihydrate / 1.) 20 min, 2.) 1,2-dichloroethane, reflux, 3 h, 3.) water, reflux, 1 h

3: 35 percent / diethyl ether; tetrahydrofuran / 1 h / Heating

With sodium acetate; trichlorophosphate; In tetrahydrofuran; diethyl ether; acetic acid;
DOI:10.1002/jhet.5570300132

Reference yield:

: 120098-72-8
1-<(2-fluorophenyl)phenylmethyl>pyrrole

: 120098-66-0
α-(1-benzyl-4-piperidinyl)-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) phosphorus oxychloride, 2.) sodium acetate trihydrate / 1.) 20 min, 2.) 1,2-dichloroethane, reflux, 3 h, 3.) water, reflux, 1 h

2: 35 percent / diethyl ether; tetrahydrofuran / 1 h / Heating

With sodium acetate; trichlorophosphate; In tetrahydrofuran; diethyl ether;
DOI:10.1002/jhet.5570300132